Synthesis and application of L-serine derivative ligands in Diels-Alder reaction between CPD and methyl acrylate

New L-serine derivative ligands were prepared and tested as co-catalyst in the DielsAlder reactions between cyclopentadiene (CPD) and methyl acrylate in the presence of several Lewis acids. The catalytic potential of the in situ formed complexes was evaluated based on the reaction yield. Bidentate serine ligands showed good ability to coordinate medium strength Lewis acids, thus boosting their catalytic activity. The synthesis of the L-serine ligands proved to be highly efficient and straightforward. Silylated serines were also prepared for posterior grafting onto inorganic materials for application in heterogeneous catalysis.